Expressions of b-FGF in human non-small cell lung cancer and its clinicopathological significance
- VernacularTitle:b-FGF在非小细胞肺癌的表达及与肿瘤血管形成和淋巴结转移关系的研究
- Author:
Longbang CHEN
;
Guiyuan LI
;
Jinghua WANG
;
Xiaojun ZHOU
;
Henghui MA
;
Wei XU
;
- Publication Type:Journal Article
- Keywords:
Basic fibroblast growth factor;
Immunohistochemistry;
Non small cell lung cancer;
Angiogenesis;
Lymph node metastasis
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the expression and distribution of b FGF in human non small cell lung cancer (NSCLC),and to evaluate the relationship between the expression of b FGF and the biological behavior of NSCLC, especially tumor angiogenesis and lymph node metastasis. Methods:The expression of b FGF and IMVD in 95 patients with NSCLC was examined using immunohistochemical methods (SP), and the relationship between the expression and many clinicopathological parameters were analyzed. Results: The positive rates of b FGF in carcinoma tissue (NSCLC) were much higher than those in the normal lung tissues nearby ( P 0.05). Conclusions: b FGF may play an important role in tumor angiogenesis and lymphatic metastasis of human NSCLC , and detection of b FGF may be a good metastasis and prognostic predictors for human NSCLC.
