The application of tissue microarray technology in pathology
- VernacularTitle:组织芯片技术在病理学中的应用
- Author:
Xiaowen YAN
;
Qin CHEN
;
Qunli SHI
;
- Publication Type:Journal Article
- Keywords:
Tissue microarray;
Tumor;
DNA microarray
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Tissue microarray is a special biologic microarray, which was invented on the base of cDNA microarray. The principle of the tissue microarray is arraying the tissue on the solid carrier according demand, then hybridizing, marking and dyeing, for researching the special expression of aimed gene or production among the different tissue. The application of tissue microarray is abroad, especially the determinant of tumor predisposing factor, the screening of the special gene and antibody, the earlier diagnosis, the therapy, and the judgment of prognosis. Compared with the traditional pathological investigation, tissue microarray has the behavior of small volume, high throughput (information), and design by different demand. Tissue microarray has important practical significance and broad market prospect in the investigation of the relation between the gene and disease (tumor), the verification of the associated gene of the disease, the development and screening of new drug, the molecular diagnosis of disease, the dynamic observation during therapy, and the judgment of prognosis.
