The relationship between the total plasma antioxidant capacity and the production of NO, IL-6 in severely burned rats
- VernacularTitle:严重烧伤大鼠血清总抗氧化能力与NO、IL-6水平相关性研究
- Author:
Baojun YU
;
Zhaofan XIA
;
Jieshou LI
;
- Publication Type:Journal Article
- Keywords:
Total antioxidant capactity;
Nitric oxide;
Interleukin 6;
Burn
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To study the alteration of total plasma antioxidant capacity(TAC), NO and IL 6 in severely burned rats, and evaluate the relationship between TAC and NO or IL 6 production. Methods: Full thickness scald burn covering 30%TBSA was produced on SD rats. At different time the blood were collected for isolating the plasma. The TAC and NO were measured according to the protocols of kits. The IL 6 was measured by radioimmunoassay. Results:TAC decreased significantly after burns, following by the increasing production of NO and IL 6. The lowest TAC level and highest production of NO and IL 6 appeared at 6 h after burns. The correlation analysis showed that TAC and NO or IL 6 had negative correlation( r=-0.839, r =-0.783). Conclusions: The low TAC level might be the cause of the high production of inflammatory mediate such as NO and IL 6. It hints that enhancing TAC level might inhibit the production of NO and inflammatory cytokines.
