Inhibition effects of verapamil on serum-induced proliferation of rabbit retinal pigment epithelial cells in vitro
- VernacularTitle:维拉帕米对血清诱导的兔视网膜色素上皮细胞增殖调节作用的研究
- Author:
Caihui JIANG
;
Maonian ZHANG
;
Kun ZHANG
;
Chunxi ZHOU
;
Jingxiang HUANG
;
Zheng GU
;
- Publication Type:Journal Article
- Keywords:
Verapamil;
Pharmacology;
Retinal pigment eqithelial cell;
Proliferative vetreoretinopathy;
Drug therapy
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the effects of verapamil on serum induced proliferation of rabbit pigment epithelial(RPE) cells so as to search for simple and effective medicine on PVR. Methods:The rabbit RPE cells(passage 2 to 5) were cultured with various concentrations of verapamil in DMEM.The effects of verapamil on the cell cycle of RPE were analyzed with flow cytometry. Results:Verapamil significantly inhibited the serum induced proliferation of RPE cells, prevented RPE from G 1 phase transiting to S phase. Conclusions:Verapamil significantly inhibits RPE cell proliferation, and it may become a promising drug on PVR.
