Differentiation and regulation of the osteoclast
- VernacularTitle:破骨细胞的分化及可溶性因子调节
- Author:
Xiaofeng ZENG
;
Jianning ZHAO
;
- Publication Type:Journal Article
- Keywords:
Osteoclast;
Cytokine;
Signal transduction
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The osteoclast is a hematopoietic cell derived from CFU GM, which is regulated by systemic hormones, soluble factors in the phase of differentiation, fusion and proliferation. The major singnaling pathways involved in osteoclastic bone resorption and formation in response to cytokine and hormones include cAMP and R PTK. The advances in our understanding of the osteoclast make it possible for us to comprehend the development and the treatment of the bone metabolic diseases.
