Inhibitory effects of chitosan on the proliferation of bovine basilar artery vascular smooth muscle cells induced by angiotensin Ⅱ
- VernacularTitle:甲壳胺对AngⅡ所诱导的乳牛基底动脉平滑肌增殖的影响
- Author:
Jian YANG
;
Qingping LI
;
Manren RAO
;
- Publication Type:Journal Article
- Keywords:
chitosan;
angiotensinⅡ(AngⅡ);
the bovine basilar artery vascular smooth muscle cells(BAVSMC S);
proliferation
- From:
Chinese Journal of Marine Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The bovine basilar artery vascular smooth muscle cells(BAVSMC S) were isolated and cultured.The effects of chitosan and enalaprilat on the proliferation of BAVSMC S induced by angiotensin Ⅱ(AngⅡ) were evaluated with MTT method,the DNA synthesis in BAVSMC S was measured by thymidine incorporation and total protein of BAVSMC S was detected by coomassie brilliant blue method.The results showed that chitosan can inhibit the proliferation of BAVSMC S induced by AngⅡ in a time and concentration dependent manner,and depress thymidine incorporation of BAVSMC S induced by AngⅡ in a concentration dependent manner chitosan can reduce the content of protein in BAVSMC S induced by AngⅡ.These findings suggested that chitosan is capable of producing an inhibitory effect on proliferation of bovine basilar artery vascular smooth muscle cells induced by AngⅡ .
