The effects of PCF on the activity and recoveration of thymocytes irradiated by ~(60)Co
- VernacularTitle:扇贝多肽对~(60)Co辐射损伤的胸腺细胞影响作用的研究
- Author:
Yuzhen WANG
;
Xiaoping LIU
;
Ruyong YAO
;
- Publication Type:Journal Article
- Keywords:
Polypeptide from Chlamys Farreri (PCF);
Thymocytes;
60 Co
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In this paper the protective effect and facillitating reconverting effect of polypeptide from chlamys farreri (PCF) on thymocytes irradiated by 60 Co ? ray were studied using the MTT chromatometry .The results showed that:(1)the damaged extents of thymocytes were increased with the radiative intensity of 60 Co ? ray elevated at the range of 3GY to 9GY compared with that in no-exposure to 60 Co ? ray group.(2)PCF could reduce 60 Co ? ray damage on thymocytes with dose dependence .In the 0.25%~4% concentration range the higher concentration of PCF the stronger protective effects of it ,but the protective effect of PCF at the concentration below 0.5% disappeared while the radiative intensity of 60 Co ? ray was at 9GY.(3)PCF could facilitate the renovation ability of thymocytes after exposure 60 Co ? ray for two hours .And only 2% concentration of PCF showed the facilitating repair process of thymocytes after radiated by 60 Co ? ray for 7 hours .(4) PCF could decrease the activity and facilitate the death of the dying thymocytes after exposure 60 Co ? ray for 19 hours. The results suggested that the protective effect and facilitating repair effect of PCF on the thymocytes damaged by 60 Co ? ray may be mediated by the antisuperoxidation of PCF.
