Synthsis of quaternary Ammonium-Glucosamine conjugate
- VernacularTitle:N-吡啶乙酰基-?-D-葡萄糖胺的合成
- Author:
Yingxia LI
;
Ni SONG
;
Shidong CHU
;
Huashi GUAN
;
- Publication Type:Journal Article
- Keywords:
glucosamine;
quaternary ammonium;
quaternary ammonium glucosamine conjugate
- From:
Chinese Journal of Marine Drugs
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Quaternary ammonium glucosamine conjugatewas prepared by a two step procedure.First,condensation of glucosamine hydrochloride with chloro acetic chloride in the presence of potassium bicarbonate in aqueous medium at 0℃ provided the N chloroacetyl derivative in 74% yield.Subsequent reaction of this intermediate with pyridine at 40℃ for 3 days gave the pyridinium conjugate in 71% yield.The structures of compounds were confirmed by IR,NMR spectra and element analysis.
