MUTATION BREEDING OF HIGH COLISTIN PRODUCTION STRAINS
- VernacularTitle:粘杆菌素高产菌株的选育
- Author:
Xi-Gui ZHOU
;
Peng-Gao DAI
;
Wei-Ling XING
;
Hong ZHANG
;
- Publication Type:Journal Article
- Keywords:
Colistin,N-methyl-N-nitro-N-nitrosoguanidine mutation,Ethionine,Resistance selection
- From:
Microbiology
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
A colistin producing strain Paenibacillus polymyxa AS1.541 was treated by N-methyl-N-nitro-N-nitrosoguanidine(NTG) for increasing yields of the antibiotic colistin.High-yield strains were obtained by selection of deregulated mutant which grow on media containing colistin,a self second metabolite,and ethionine,an analogue of methionine.Some of these mutants have higher yield of colistin than that of the parent strain.
