Studies on antineoplastic constituents from marine bryozoan bugula neritina inhabiting south china sea (IV):Isolation and structural elucidation of bryostatins 8 and 16
- VernacularTitle:中国南海总合草苔虫抗癌活性成分研究(IV)Bryostatin8,16的分离与结构鉴定
- Author:
Houwen LIN
;
Yanghua YI
;
Xinsheng YAO
;
Houming WU
;
- Publication Type:Journal Article
- Keywords:
Bugula neritina;
Bryostatins;
Antineoplastic agents
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Eight active compounds were isolated from Bugula neritina Linnaeus collected off Dapen Bay in Guandong province, guided by P 388 bioassay system by a combination of successive chromatographies and preparative HPLC. By intensive analysis of the data of high resolution 2D NMR spectrum and ESI MS, their structures were elucidated as known bryostatins--bryostatin 4, 5, 6, 8, 10, 11, 16 and 18, among which bryostatin 8 and 16 were for the first time obtained from this animal in South China Sea and they showed significant antineoplastic activities in vitro.
