OK-432 Induced IL-12 and Th1 Cytokines Production in Tumor Bearing Mice
- VernacularTitle:OK-432对荷瘤小鼠脾细胞IL-12及Th1细胞因子分泌的诱导作用
- Author:
Xianghui WANG
;
Toshihiro FUJIMOTO
;
Bin ZHANG
;
Masayoshi MAI
;
Fulu CHAI
;
- Publication Type:Journal Article
- Keywords:
OK 432;
cytokine;
immunoregulation;
immunotherapy;
melanoma
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess potential mechanisms responsible for the antitumor activities of the streptococcal preparation OK 432.Methods: C57BL/6 mice were transplanted subcutaneously with 5?10 5 B16 melanoma cells and treated with OK 432 (1KE/week?3) or saline (control) intraperitoneally 3 days after the inoculation and tumor size was measured biweekly. The effects of OK 432 on splenocyte cytokines (IL 2, IL 4, IL 6, IL 10, IL 12, IFN ?) production of tumor bearing mice were investigated both in vitro and in vivo. Results: OK 432 significantly inhibited B16 melanoma growth and lengthened the survival time of the mice as compared with control ( P
