Immunotherapeutic Effects of Elemene Combo Tumor Cell Vaccine on Hca-F and Changes of IL-10 and IL-12 Secretion by Splenocytes of Treated Mice
- VernacularTitle:榄香烯复合瘤苗对Hca-F肝癌小鼠的免疫治疗效应及对IL-10与IL-12分泌的影响
- Author:
Weihong ZHAO
;
Guangxia SHI
;
Xiaolin YUAN
;
Zhenchao QIAN
;
- Publication Type:Journal Article
- Keywords:
elemene;
tumor cell vaccine(TCV);
immunotherapy;
IL 10;
IL 12
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the immunotherapeutic effects of elemene combo tumor cell vaccine(EC TCV) on Hca F murine hepatic carcinoma and changes of IL 10 and IL 12 secretion by splenocytes of treated mice. Methods: BALB/c mice inoculated with Hca F were treated with EC TCV, CY, EC TCV+CY or PBS control, tumor growth was measured, concentration of IL 10 and IL 12 in supernatants of mixed splenocytes and Hca F culture(MSTC) was assayed with ELISA. Results: After EC TCV immunotherapy and CY chemotherapy, the latent period of tumor growth prolonged, mean tumor weight (MTW) decreased, even no nodule was observed in EC TCV+CY chemoimmunotherapy group, the concentration of IL 10 in supernatants of MSTC of EC TCV immunotherapy group decreased significantly(1.82?0.29 pg/ml, P
