ULTRA-PATHOLOGICAL STUDY ON THE SYNCYTIUM OF SCHISTOSOMA MANSONI EXPOSED TO CYCLOSPORIN A IN VITRO
- VernacularTitle:环孢素A体外抗曼氏血吸虫合胞体超微结构的变化
- Author:
Jianfa LIU
;
L.H.CHAPPELL
;
- Publication Type:Journal Article
- Keywords:
cyclosporin A, Schistosoma mansoni , syncytium, ultrastructure
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective] To study the ultra pathological changes of syncytium of Schistosoma mansoni after cyclosporin A (CsA) treatment. [Methods] MF1 mice were infected with Schistosoma mansoni cercariae. Six weeks later, the adult worms were recovered by portal vein perfusion. After the worms were exposed to CsA of 20 ?g/ml for 24 h, the drug induced damage of the worm surface was observed by SEM and TEM. [Results] Incubation of male and female schistosomes with 20 ?g/ml of CsA for 24 h resulted in disruption of the tegument and rupture of the spines. Progressive surface damage and swelling and vacuolization of the tegument led to eventual disruption of the syncytium. [Conclusion]The antischistosomal action of CsA is direct, the syncytium is the main site for CsA attack.
