THE STUDY ON THE MECHANISM OF PROTECTING ERY- THROCYTE DEFORMABILITY OF PSS AND PGMS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
- VernacularTitle:藻酸双酯钠和甘糖酯对急性心肌梗死患者红细胞变形能力保护作用的机制探讨
- Author:
Chengyu LIU
;
Xiuli WANG
;
Xinqiang JI
;
Runluan TAN
;
- Publication Type:Journal Article
- Keywords:
PSS;
PGMS;
myocardial infarction;
erythrocyte deformability;
adenosine triphosphatase;
glutathione peroxidase
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the mechanism of protecting erythrocyte deformability (ED) of polysaccharide sulfate(PSS)and propyllene glycolmannurate sulfate(PGMS) in patients with acute myocardial infarction (AMI). The erythrocyte filtration index(EFI),erythrocgte membrane Na+,K+-ATPase .glutathione peroxidase(GSH-Px)activity and lipid peroxide(LPO) were measured in 52 patients with AMI. Meanwhile the effects of PSS and PGMS on EFI, Na+,K+-ATPase ,GSH-Px and LPO in AMI patients were observed in vitro. The results showed that the EFI and LPO were markedly higher ,Na+ ,K+-ATP ase and GSH-Px were si-hnificantly lower in patients than those in control(P0. 05). These results indicate that PSS and PGMS could improve the ED in patients ,and the efficacy of PSS or PGMS was related to enchancement of erythrocyte membrane ATP-ase anci GSH-Px activity.
