The effects of Silymarin on the inhibition of nonenzymatic glycation and oxidation in kidneys of streptozocin-induced diabetic rats
- VernacularTitle:水飞蓟素对糖尿病大鼠肾组织非酶糖化及氧化的影响
- Author:
Xiangjin XU
;
Jiaqing ZHANG
;
Qingling HUANG
;
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Nonenzymatic glycation;
Silymarin
- From:Chinese Journal of Diabetes
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Silymarin 100mg?kg~(-1)/d was given to streptozotocin induced diabetic rats for 9 weeks. The results showed that LPO,fructosamine and the fluorescence intensities of AGEs,pentosidine,MDA adducts,HNE adducts in renal cortex of diabetic rats were significantly higher than in normal control rats. After being treated with Silymarin,LPO and the fluorescence intensities of AGEs,pentosidine,MDA and HNE adducts in renal cortex were significantly reduced than in untreated DM group.The albumin excretion in Silymarin group was significantly decreased than in untreated DM group.Silymarin may inhibit nonenzy- matic glycation and oxidation in kidneys of streptozotocin-induced diabetic rats and control the diabetic chronic complication.
