EFFECT OF FISH OIL ON B-ADRENOCEPTORS AND THE ACTIVITY OF ADENYLATE CYCLASE ON MYOCARDIAL MEMBRANE IN RATS
- VernacularTitle:鱼油对大鼠心肌细胞膜上?-受体和腺苷酸环化酶活性的影响
- Author:
Jianzheng ZHOU
;
Baojie WU
;
Xiumei ZHANG
;
- Publication Type:Journal Article
- Keywords:
fish oil;
EPA and DHA;
adenylate cyclase (AC);
?-adrenoceptor
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of fish oil on B-adrenoceptors as well as the activity of adenylate cyclase (AC) on rat myocardial membrane were investigated. Supplementation with fish oil had no significant effect on basal activity of AC on myocardial membrane, whereas it could markedly inhibit the AC activity stimulated by isoproterenol (ISO). Radioligand binding assays showed that supplementation with fish oil had no effect on Bmax, and Kd, compared with saline control. However, supplementation with sheep oil could markedly reduce both the Ka and Bmax, compared with saline control. And the Ka value of sheep oil group was greatly decreased than that of fish oil group. The results suggested that supplementation with fish oil affected mainly on the activation of AC and not on B-adrenoceptor itself.
