EFFECTS OF TAURINE ON CALCIUM CURRENT IN SINGLE VENTRICULAR CELLS OF GUINEA PIGS
- VernacularTitle:牛磺酸对豚鼠单一心室肌细胞钙离子电流的作用
- Author:
Lijuan WANG
;
Jinming LI
;
Tianhui CHANG
;
Liying HAO
;
Yuping WANG
;
Keyi ZHANG
;
- Publication Type:Journal Article
- Keywords:
Taurine (Tau );
calcium current (Iea );
calcium channel blockade;
patch clamp method
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
With patch clamp method,the effects of taurine (Tau) on slow inward calcium current (Ica) were investigated in single ventricular cells of guinea pigs. Tau decreased Ica in a dose- and voltage-dependent mode,but had little effect on reversal potential. Tau 0. 1 umol - L-1 decreased Ica by 17% and its maximal effective concentration was near 100 umol -L '. The initial block of Tau had already reached by 47% after a rest out of stimulation. Tau facilitated the reduction of lea through increasing clamp pulse frequency. The obtained results suggested that it decreased Ica in a use-dependent manner.
