A STUDY ON CHITOSAN INHIBITING FIBROBLAST PROLIFERATION IN VITRO
- VernacularTitle:甲壳胺及N—乙酰葡糖胺抑制人成纤维细胞增殖的研究
- Author:
Yiwu HUANG
;
Fang LU
;
- Publication Type:Journal Article
- Keywords:
Chitosan;
N-acetyl-d-glucosamine;
biodegradation;
fibroblast
- From:
Chinese Journal of Marine Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
We use chitosan and n -acetyl -d -glucosamine to inhibit fibroblast proliferation which was cultured in vitro. The result shows that n - acetyl - d - glucosamine: ID50=16. 35mg/L, chitosan: ID50=69. 59mg/L. We also plant the chitosan membrane to the rabbit body to test its bio-degradation. The result shows that the molecular weight of chitosan drops 17% and 6% after 25 days and 18 days, respectively. On the basis of these results, we have obtained a conclusion that we can probably use chitosan to continuously release n-acetyl -d-glucosamine which can inhibit fibroblast proliferation effectively.
