ANTITUMOR EFFECT OF SOME COMPOUNDS WITH UNSATURATED LACTONE FROM MARINE NATURAL PRODUCTS
- VernacularTitle:几种不饱和内酯二萜类海洋天然产物的抗肿瘤作用
- Author:
Shibo XU
;
Hui XIANG
;
Jingyu SU
;
Yongli ZHONG
;
- Publication Type:Journal Article
- Keywords:
unsaturated lactone;
EAT cell;
S180 cell;
antitumor effect.
- From:
Chinese Journal of Marine Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The compounds (8R23, 9R221 , 9R6222, 10R221 , H1105) extracted from the soft coral, with unsaturated lactone, showed antitumor effect on EAT, IC50 was 18. 6,85. 8,67. 8,3d. 9, 3.05umol. L-1, respectively; IC50 on S180 was 10. 7,44. 4,30. 9,9. 95,2. 4umol. L-1, respectively. 8R23, 10R221 obviously increased the level of cAMP in the EAT cell. 8R23, 10R221 , III 105 also inhibited DNA synthesis of the EAT cell.These results indicated that these compounds might have antitumor effect, but the mechanism was unknown.
