Itraconazole injection for treatment of fungal infections in the patients with hematological malignancies
- VernacularTitle:伊曲康唑注射液治疗血液恶性肿瘤伴发真菌感染疗效观察
- Author:
Hui-Qing YU
;
- Publication Type:Journal Article
- Keywords:
Itraconazole;
Fungal;
Leukemia;
Lymphoma
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of itraconazole in the treatment of fungal infection in the patients with hematological malignancies.Method:53 patients with malignant hematologic diseases were divided into three groups:empirical treatment group, suspected fungal infection group and established group.Itraconazole was given in a dose of 200mg twice daily in the first and the second days, from the third day in a dose of 200mg once daily.Response was established as normalization of temperature in the patients receiving itraconazole, and disappearance of clinical signs in the patients with suspected or established infection.Result:The 31 patients were eligible for efficacy evaluation for empirical treatment,and 25 responded to itraconazole(80.65%);of 9 established patients,6 responded to itraconazole(66.67%);of 13 suspected infection patients, 10 responded to itraconazole(76.92%).As to the side effects, there were no rigor and fever, but hepatotoxiciy were present in 5.66%, and no nephrotoxicity.Conclusion:Itraconazole is a highly effective drug with low side effects in treatment of fungal infections.But the hepatic and renal function tests must be carried out regularly when itraconazole infection is used.
