Protective Effect of Danxiong Recipe on Brain in Hypoxia Mice
- VernacularTitle:丹芎方对缺氧小鼠脑组织的保护作用
- Author:
Yi CHEN
;
Xiaorong LI
;
Jian GAO
;
Yu TANG
;
Mingming WANG
;
Ming XUE
;
- Publication Type:Journal Article
- Keywords:
Danxiong Recipe;
Superoxide dismutase;
Malondiadehyde;
Lactic acid;
Nitric oxide synthase
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of Danxiong Recipe (DR) on brain in hypoxia mice.Methods Sixty mice were equally randomized to 6 groups:normal group,model group,propranolol group and low-,model- anti high-dose DR groups.Except the normal group,the mice in other groups were given the corresponding drug intra- gastrically according to the experimental design,once a day,for 7 days.After treatment,the survival time under nor- mobaric hypoxia condition in different groups was calculated.Meanwhile,the activities of superoxide dismutase(SOD) and nitric oxide synthase (NOS),and the contents of malondiadehyde (MDA) and lactic acid (LD) in the brain ho- mogenate were detected with test kit.Results The results showed that DR could prolong the survival time of the mice, inhibit obviously the abnormal increase of MDA and LD,reduce NOS activity,and enhance SOD activity in mice brain. Conclusion DR exerts protective effect on brain in hypoxia mice under normal pressure.
