Study on Hemolysis,Allergic Reaction and Stimulation of Polydatin Injection
- VernacularTitle:虎杖苷注射液的溶血、过敏及刺激试验
- Author:
Xiongwei XU
;
Guangqing QIU
;
Meizhu LI
;
Xiaojuan CHEN
;
Lianhao XU
;
Lijuan CHEN
;
- Publication Type:Journal Article
- Keywords:
Polydatin injection;
Hemolysis;
Allergic reaction;
Stimulation reaction
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the hemolysis,allergic reactions and stimulation of Polydatin Injection(PI),thus to provide evidence for clinical medication.Methods Hemolysis was observed by in-vitro rabbit blood hemolysis.Sys- temic allergy and passive skin allergy were tested on guinea pigs and rats.Vascular stimulation and muscle stimulation were tested on rabbits.Results There was no hemolysis or reaction in erythrocyte agglutination 30,60 and 180 rain after adding PI.No systemic anaphylaxis was found in guinea pigs.There was no skin allergy passive in rats.There was no vascular stimulation or muscle stimulation after injecting PI(0.39 mg/mL)5.6 mg/kg into rabbit ears.Con- clusion Under experimental conditions,PI(0.39 mg/mL)shows no hemolysis in vitro or agglutination reaction;it has no systemic anaphylaxis or passive skin allergy;it either has no stimulating effect in rabbit auricular vessels and muscles.
