Therapeutic Effect and Mechanism of Yingqiling for Hyperthyroidism(Graves Disease)
- VernacularTitle:瘿气灵对毒性弥漫性甲状腺肿的治疗作用及其机理探讨
- Author:
Wenping ZHANG
;
Yangmo HUANG
;
Jing ZHANG
;
Shihuang LIAO
;
- Publication Type:Journal Article
- Keywords:
HYPERTHYROIDISM/TCM-WM therapy;
YINGQILING/therapeutic use;
APOPTOSIS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of Yingqiling for Graves disease(GD)and to explore its therapeutic mechanism.Methods Eighty GD patients were equally randomized into two groups.The treatment group received oral use of Yingqiling Tablets(mainly composed of Radix Pseudostellafiae,Radix Astragali,Radix Ophiopogonis,Fructus Schisandrae Chinensis,Spica Prunellae,Semen Ziziphi Spinosae,Concha Ostreae, Bulbus Fritillariae Thunbergii,Radix Ranunculi Ternati,Radix Scrophulariae,Radix Paeoniae Rubra and Thiamazole 1 mg),and the control group received Thiamazole Tablets.After treatment for 2 months,the therapeutic effect was evaluated and the changes of serum levels of thyroglobulin antibodies(TGAb),thyroid peroxidase antibody(TPO-Ab),and the apoptosis-associated factors of soluble Fas(sFas)and bcl-2 were observed before and after treatment.Results Twenty-one patients were clinically effective,13 markedly effective,6 effective,0 ineffective,and the total effective rate was 100% in the treatment group;14 patients were clinically effective,13 markedly effective,7 effective,6 ineffective,and the total effective rate was 85.0% in the control group.The effect in the treatment group was superior to the control group(P
