In-vitro Inhibitory Effects of Edomin on Herpes Simplex Virus TypeⅠ and Ⅱ
- VernacularTitle:大黄素体外抗单纯疱疹病毒Ⅰ型和Ⅱ型的药效学研究
- Author:
Ni LIU
;
Yirong MENG
;
Junli ZHANG
;
Yutong ZHU
;
- Publication Type:Journal Article
- Keywords:
EMODIN/pharmacology;
HERPES SIMPLEX/TCD therapy;
SIMPLEX VIRUS;
CELL CULTURE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effects of emodin on herpes simplex virus typeⅠandⅡ(HSV-Ⅰand HSV-Ⅱ)in vitro.Methods The antivirus effects of the derivates of anthraquinones component from rhubarb (emodin,rhein,physcion,aloeemodin,and chrysophanol)on HSV-Ⅰand HSV-Ⅱin rabbit renal cells were evaluated by means of the inhibition of cytopathic effect.Results Emodin can inhibit the cytopathic effect of HSV-Ⅰat the tolerance dosage of 3.75?g/mL and can inhibit the cytopathic effect of HSV-Ⅱat the tolerance dosage of 15.0?g/mL.Conclusion Emodin has in-vitro antivirus effects on herpes simplex virus typeⅠandⅡ,while other derivates such as rhein,physcion,aloe-emodin,chrysophanol have no such effects.
