Analgesic effect of oxysophoridine and its mechanism
- VernacularTitle:氧化槐定碱镇痛作用及其机制研究
- Author:
Wan-Xia YAO
;
Jun-Jun ZHOU
;
Lin YAN
;
Shao-Ju JIN
;
Yuan-Xu JIANG
;
- Publication Type:Journal Article
- Keywords:
oxysophoridine(OSR);
Verapamil(Ver);
analgesia;
nitric oxide(NO)
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the analgesic effect of oxysophoridine(OSR)and the influence of verapamil(Ver)on the antinociception of OSR when two drugs were co-administrated in mice.Methods The number of writhing within 15 min after ip different doses of OSR was observed in painful mouse mo- dels caused by acetic acid.The hot plate method was used to assess nociceptive sensitivity of CaCl_2 and Ver before ip OSR.Nitric oxide(NO)in serum was measured by spectrophotometry.Results The number of writhing was decreased and the latency of licking the hind paws was prolonged in a dose-dependent manner after ip OSR.The antinociception of OSR could be antagonized by CaCl_2 and enhanced by Ver.No inter- ference was detected in serum volume of NO.Conclusion These results suggest that OSR can antagonize the acute pain caused by acetic acid and hot plate in a dose-dependent manner in mice.Calcium channel blocker could enhance the effect of OSR.
