Analysis of Blood Tacrolimus Concentrations in Renal Transplant Recipients
- VernacularTitle:肾移植患者全血他克莫司浓度监测结果分析
- Author:
Huawen XIN
;
Qing LI
;
Xiaochun WU
;
Dan SU
;
Lei XIONG
;
Airong YU
;
Yang SHEN
;
Guowei ZHANG
;
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Tacrolimus;
Blood concentration;
Liver and renal function;
Blood route
- From:
Chinese Journal of Pharmacoepidemiology
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic range of tacrolimus and effects of tacrolimus on liver and re- nal functions and blood routine in renal transplant recipients.Method:The whole blood tacrolimus concentration was meas- ured by micro-particle enzyme immunoassay(MEIA).Blood tacrolimus concentrations in 390 cases of renal transplant re- cipients were analyzed.The effects of tacrolimus on liver and renal function and blood routine were also studied.Result: The blood tacrolimus concentrations in 377 of 390 cases were within the range from 3 to 15?g?L~(-1).Their blood tacrolimus concentration differed greatly in renal transplant recipients within 6 months after transplantation.Their blood tacrolimus concentration was gradually decreased as time went on.Tacrolimus with therapeutic dosage had no effects on liver and renal function and blood routine.Conclusion:The therapeutic ranges of tacrolimus with MEIA were as follows:5 to 15?g?L~(-1) within 3 months after transplantation,5 to 10?g?L~(-1)between 4 to 6 months after transplantation,3 to 10?g?L~(-1)6 months after transplantation.The administration of tacrolimus had no effects on the liver and renal function and blood routine in re- nal transplant recipients.
