The effect of infrasound on the level of somatostatin and cholecystokinin in rat duodenal mucosa
- VernacularTitle:次声对大鼠十二指肠黏膜生长抑素及胆囊收缩素水平的影响
- Author:
Xiao-Yan GUO
;
Jin-Hai WANG
;
Lei DONG
;
Jing-Zao CHENG
;
- Publication Type:Journal Article
- Keywords:
Infrasound;
Rat;
Somatostatin;
Cholecystokinin
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of infrasound of different frequencies and intensities on the levels of somatostatin(SS)and cholecystokinin(CCK)in rat duodenal mucosa.Methods A total of 140 male Sprague- Dawley rats were randomly divided into a control group,an 8 Hz-90 dB group,a 8 Hz-130 dB group and a 16 Hz- 130 dB group.The experimental groups were exposed to infrasound of 8 Hz-90 dB,8 Hz-130 dB or 16 Hz-130 dB,re- spectively,for 2 hours a day,and the control group was put under sham infrasonic exposure.After being exposed for 1, 7,14,21 and 28 days,7 rats were randomly selected from each group and underwent SS and CCK levels detection in duodenal mucosa by microarray radioimmunity method.Results Compared with the control group,the SS and CCK levels of duodenal mucosa did not change significantly after exposure for 1 day.The SS and CCK levels of duodenal mu- cosa significantly increased in 8 Hz-90 dB group,8 Hz-130 dB group and 16 Hz-130 dB group after exposure for 7,14, 21 and 28 days(P
