Anti-neoplastic effect of chitosan-polyaspartic acid-5 fluorouracil nanoparticles on tumor growth of the implanted gastric cancer in nude mice
- VernacularTitle:壳聚糖-聚天冬氨酸-5氟尿嘧啶纳米粒子对小鼠的抑瘤作用
- Author:
Dan-Ying ZHANG
;
Li-Li WU
;
Ji-Yao WANG
;
Yongli ZHENG
;
Ling DONG
;
Xizhong SHEN
;
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Nanoparticles;
Neoplasms,experimental;
5-fluorouracil;
Chitosan
- From:
Chinese Journal of Digestion
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare chitosan-polyaspartic acid-5 fluorouracil (CTSPasp-5FU) nanoparticles and to investigate its anti-neoplastic effect and toxicity.Methods CTS-Pasly5FU nanopartieles were synthesized by ion gelatifieation.BALB/C nude mice were injected with gastric carcinoma cell line SGC- 7901 mass subcutaneously near nape to establish human gastric carcinoma model.Then they were randomly al- located into chitosan-polyaspartie acid -5fluorouracil(CTS-Pasp-SFU,containing 5-FU 1.25mg/kg) group, 5-FU (1.25mg/kg) group and normal saline group.Tumor weight was measured and the colony forming unit- granulocyte and maerophage (CFU-GM) was investigated.Results The drug content of CTS-Pasp-5FU was 40.2% and the encapsulation efficiency was 34.9%.Compared with normal saline group,tumor volume of 5-FU group and CTS-pasp-5-FU group were significantly decreased 21 days after treatment (P
