Effects of simvastatin on the expression of RANTES in patients with hypercholesterolemia
- VernacularTitle:辛伐他汀对高胆固醇血症患者RANTES表达的影响
- Author:
Yong-Hong LI
;
Zhi-Ming GE
;
Zhi-Qiang LI
;
Shan-Lang CAI
;
Yi AN
;
Qi-Xin WANG
;
Guo-Xiong DONG
;
- Publication Type:Journal Article
- Keywords:
Hypercholesterolemia;
RANTES;
AngiotensinⅡ;
Simvastatin
- From:
Chinese Journal of Emergency Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
6.24 mmol/L) and sixty healthy persons in the health center of our hospital were investigated as hyperhpidemia group (Hyperlipidemias) and control group (Controls) respectively.Hyperlipidemias were given simvastatin 20 mg?d~(-1) for twelve weeks (Statins).Blood samples of ulnar vein were extracted from Statins at the end of twelve weeks as well as Controls and Hyperhpidemias at the beginning of the experiment. Blood serum,plasma and mononuclearcell were extracted and stored at a refrigerator of-80℃.The level of plasma angiotensinⅡwas detected by the method of radioimmunity.While the expression of RANTES mRNA and protein on mononuclearcell were assessed by real time reverse transcription polymerse chain reaction and Western blot respectively.Results①The plasma angiotensinⅡof Hyperlipidemias was higher than that of Controls [(92.13?22.03) vs (50.85?12.12),P
