PADI4 mRNA expression in peripheral blood mononuclear cells of rheumatoid arthritis
- VernacularTitle:RA患者易感基因肽酰基精氨酸脱亚氨酶4mRNA的表达及其意义
- Author:
Li-Li CHANG
;
Yan-Ying LIU
;
Zhan-Guo LI
;
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Citrulline;
Peptidylarginine deiminase
- From:
Chinese Journal of Rheumatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of PADI4 mRNA in the initiation and development of rheumatoid arthritis(RA)and its correlation with clinical features.Methods Fifty-three RA patients,27 OA patients and 30 healthy volunteers were included in the study.The real-time-fluorescence quantitative PCR method was used to measure the expression level of PADI4 mRNA.The level of Anti-CCP antibody and DAS 28 of the RA patients were measured at the same time.Results It was shown that the level of PADI4 mRNA from RA was significantly higher than that of the OA and control group(P
