The comparison between the therapeutic effect of the combination of ~(99m)Tc-methnetium methylene diphosphonate and colloidal chromic phosphate phosphonium-32 and each treatment alone in rats with adjuvant arthritis
- VernacularTitle:~(99m)Tc-MDP联合胶体磷酸铬~(32)P与单一疗法对大鼠佐剂型关节炎治疗效果比较
- Author:
Qiang-Rong GU
;
Yan XU
;
Shao-Hua LI
;
Jian-Chao GUI
;
Li-Ming WANG
;
- Publication Type:Journal Article
- Keywords:
Arthritis,experimental;
Injections,intra-articular;
Colloidal chromic phosphate ~(32)p;
Technetium 99m medronate
- From:
Chinese Journal of Rheumatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effect of the combination of ~(99m)Tc-methnetium methylene diphosphunate and colloidal chromic,phosphate ~(32)p with the monotherapies in rats with adjuvant arthritis(AA).Methods In this study,50 Sprague-Dawley rats were randomly divided into five groups with 10 rats in each:normal control group(arthritis induced and treated with the same volume of normal saline via the same administration route),AA control group(arthritis induced with adjuvant and treated with normal sa- line),~(32)p colloid group(arthritis induced with adjuvant and treated with single intra-articular injection of col- luidal chromic phosphate ~(32)p 0.74 MBq and intra-peritoneal injection of normal saline every other clay),~(99m)Tc- MDP group(arthritis induced with adjuvant and treated with intra-peritoneal injection of ~(99m)Tc-MDP 2.5?10~(-3)?g/kg every other day and single intra-articular injection of normal saline),combination group(arthritis in- duced with adjuvant and treated with the combination of the two drugs).The diameter of the left hind ankle, serum levels of turnout necrosis factor(TNF)and interleukin-1?(IL-1?),and the pathological changes of an- kle joints were tested at different time points.Results The diameter of the left hind ankle at week 4 was smaller in the combination group than that of the ~(32)p colloid treatment alone group [(7.11?0.34)mm vs(7.57?0.29)mm,P
