Study of the role of glucocorticoid receptor-alpha and beta mRNA of the peripheral blood mononuclear cells in the pathogenesis and treatment of dermatomyositis/polymyositis
- VernacularTitle:糖皮质激素受体?及?在皮肌炎/多肌炎患者发病与治疗中的作用
- Author:
Jiu-Hong LI
;
Gui-Jiao BI
;
Ning ZHAI
;
Fang-Ji SONG
;
- Publication Type:Journal Article
- Keywords:
Receptors;
glucocorticoid;
Dermatomyositis;
Polymyositis;
Monocytes
- From:
Chinese Journal of Rheumatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of glucocorticoid receptor-alpha and beta(GR?and GR?)mRNA of peripheral blood mononuclear cells(PBMCs)in patients with dermatomyositis/polymyositis (DM/PM)and analyze their association with the pathogenesis and clinical response to glucocorticoid therapy. Methods The expression of GR?and GR?mRNA in PBMCs from 20 normal controls and 36(24 steroid- sensitive,12 steroid-resistant)patients with DM/PM were detected by reverse transcription polymerase chain reaction(RT-PCR).Results Compared to normal controls,the expression of GR?mRNA in the DM/PM was significantly decreased(P
