Effect of Abnormal Savda Munziq on MDR and Expression of mRNA of Bel/Fu Cell Line
- VernacularTitle:维药异常黑胆质成熟剂总黄酮对Bel/Fu细胞株多药耐药性及mRNA表达的影响
- Author:
Mayinur
;
Hamurat
;
Abliz
;
- Publication Type:Journal Article
- Keywords:
Uighur medicine;
Bel/Fu cell line;
MDR;
RT-PCR;
ASMq
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Abnormal Savda Munziq (ASMq) on MDR and expression of mRNA of Bel/Fu cell line. Methods Several genes expression including MDR1, MRP, TOPOII? and GST-? were analyzed by RT-PCR. Results ASMq has been found to down-regulate MDR1 gene and simultaneously up-regulate TopoⅡ?mRNA. Conclusion ASMq can reverse the drug resistance against 5-Fu in Bel/Fu cells. Inhibition of MDR1 mRNA and up-regulate TopoⅡ? mRNA may contribute to the mechanisms.
