Effects of intensive insulin treatment on the prognosis of severe multiple trauma patients
- VernacularTitle:强化胰岛素治疗对严重多发伤患者预后的影响
- Author:
Ling ZHAO
;
Xiang-Dong GUAN
;
Shu-Zi GAO
;
Yong-Bo LI
;
Lei CHU
;
Fan ZENG
;
Yu-Yu HOU
;
- Publication Type:Journal Article
- Keywords:
Severe multiple trauma;
Cytokines;
Intensive insulin therapy;
Prognosis
- From:
Chinese Journal of Emergency Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
16 and the distribution of severe trauma more than 2 anatomic parts.They were randomly divided into two groups:intensive insulin treatment group(n=31)and control group(n=31).Intensive insulin treatment group received insulin with insulin pump in order to maintain blood glucose levels at 4.0-6.1 mol/L,while the control group received routine insulin treatment in order to mmaintain blood glucose levels at 10.0- 11.0 mol/L.Plasma levels of TNF-?,IL-1,IL-6, CRP,APACHEⅡscores and cure rate were analyzed before and after the treatment.Data was expressed as mean?standard deviation.Two- tailed T test and ANOVA were used for comparison in SPSS 10.0,and changes were considered as statistically significant if P value was less than 0.05.Results After the intensive insulin treatment, patient's hemodynamic parameter apparently improved,APACHEⅡscores descended,and the levels of TNF-?, Ib-1,IL-6,CRP all declined,in comparison with control group,there were significant differences. Intensive insulin treatment might improve patient's general condition and decrease complications and mortality of severe multiple trauma.
