Change and role of kidney interstitial dendritic cells in mice with multiple organ dysfunction syndrome
- VernacularTitle:肾脏间质树突状细胞在多器官功能障碍综合征中的变化与作用
- Author:
Hong-Wei WANG
;
Jiang-Yang LU
;
Xiao-Hong WANG
;
Guang TIAN
;
Ling LI
;
Yi YANG
;
- Publication Type:Journal Article
- Keywords:
Multiple organ dysfunction syndrome;
Dendritic cells;
Electron microscope;
CD205;
I-A~b
- From:
Chinese Journal of Emergency Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of kidney interstitial dendritic cells in irnmunodissonance moechanism in mice with multiple organ dysfunction syndrome(MODS).Method The model of MODS wasmade by injecting zymosan into the peritoneal caiecty of C57BL/6 miee,and the mice were randomly divided into 5 groups,namely,normal,3～6 hours,12～48 hours,5～7 days,10～12 days after administrating zymosan. Pathological changes of kidney interstitial dendritic cells were observed by transmission electronic microscopes. Specific sudaee markers CD205,CD11e,CDSO,MHCⅡmolecules I-A~b,CD4~+ and CD8~+T lymphocyte subgroups in peripheral blood were detected by immunohistochemistry and flow cytomctry.Results In acute injury stage,in comparison with normal group,interstitial dendritic cells had a continuous proliferation with high expression of CD80 and I-A~b(P
