Correlation between expression of heparanase and invasion of choriocarcinoma
- VernacularTitle:乙酰肝素酶与绒毛膜癌侵袭能力的关系
- Author:
Rong YU
;
Yi ZHANG
;
Jing-Ting CAI
;
- Publication Type:Journal Article
- Keywords:
Glucuronidase;
Choriocarcinoma;
Neoplasm invasiveness
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the expression of heparanase(Hpa) and the invasion of choriocarcinoma by studying the expression of Hpa in human choriocarcinoma cell lines JEG-3 and JAR and human chorionic villous tissues.Methods(1)Matrigcl invasion assays were used to detect in vitro invasive ability of JEG-3 cells and JAR cells.(2)Expression of Hpa protein in the human chorionic villous tissues and choriocarcinoma cell lines(JEG-3 cells and JAR cells)were detected by immunocytochemistry and western blot.Results(1)The invasive cell number was significantly larger in JEG-3 cells than in JAR cells(191?17 vs 106?13,P
