Effect of Cyclosporin Based Triple Immunosuppressive Therapy on Glucose Tolerance in Renal Transplant Recipients
- VernacularTitle:含环孢素的三联免疫治疗方案对肾移植受者糖耐量的影响
- Author:
Airong YU
;
Huawen XIN
;
Xiaochun WU
;
Qing LI
;
- Publication Type:Journal Article
- Keywords:
Post-transplantation diabetes mellitus;
Plasma glucose;
Impaired glucose tolerance;
Cyclosporin A;
Prednisone
- From:
Chinese Journal of Pharmacoepidemiology
2007;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of cyclosporin A based triple immunosuppressive therapy on the plasma glucose in renal transplant recipients.Method:680 renal transplant recipients treated with cyclosporine A combined with prednisone and mycophenolate mofefil from Jan.1996 to May 2007 were analysed.Result:The morbidities of impaired fast- ing glucose,impaired glucose tolerance and post-transplantation diabetes mellitus (PTDM) were 3.97%,5.15% and 8.09%,respectively.The daily doses and concentrations of CsA and the daily doses of prednisone in the impaired glucose tolerance group and PTDM group were significantly higher than those in the normal plasma glucose group.Conclusion:The daily doses and concentrations of CsA and the daily doses of prednisone were closely related to the impaired glucose toler- ance and PTDM of renal transplant recipients.
