Effect of carvedilol on distribution and expression of connexin43
- VernacularTitle:卡维地洛对连接蛋白43的分布及数量的影响
- Author:
Kui CHEN
;
Yan-Hong TANG
;
Cong-Xin HUANG
;
Xi WANG
;
Okello EMMY
;
Ming-Wei BAO
;
Han-Hua DENG
;
Shu-Ping HU
;
Jian GE
;
Kui CHEN
;
- Publication Type:Journal Article
- Keywords:
Carvedilol;
Infarction;
Ventricular arrhythmia;
Cx43;
Cardiac arrhythmic
- From:
Chinese Journal of Emergency Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of carvedilol on the expression of Cx43 in rabbits with myocardial infarction and its association with ventricular arrhythmia.Method Thirty-six rabbits were randomly divided into three groups in equal number(n=12),namely,myocardial infarction(MI)group,carvedilol group and sham MI group.Rabbits of carvedilol group were administered with carvedilol 5 mg kg~(-1)?d~(-1)after MI induced,while no carvedilol was administered to the MI group.The following observations were made:(1)Cx43 density of the epicardial border zone measured by quantitative immnuoconfocal laser scanning,and(2)cx43 protein expression analyzed by western blot.Results(1)Under immunoconfocal laser microscope,the relative density of Cx43 was(0.16?0.06)% in the infarction group and was(0.32?0.11)% in the sham MI group [(0.68?0.15)%,both P
