Effect of iipopclysaccharide on ENaC expression in the lung of rats with acute lung injured
- VernacularTitle:内毒素对大鼠肺内钠通道表达的影响
- Author:
Hao-Jun FAN
;
Hong-Yan HU
;
Qin-Fang HAO
;
Shu-Ying LIU
;
Jian-Peng ZHANG
;
You-Ning LIU
;
- Publication Type:Journal Article
- Keywords:
Endo-pulmonary natrium channel (ENaC);
Acute lung injury;
Lipopolysaccharide(LIPS)
- From:
Chinese Journal of Emergency Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of lipopolysaccharide(LPS)on the endo-pulmonary natrium channel(ENaC)expression in the lung of rats with acute lung injured.Method Sixteen rats were randomly divided into normal control group and LPS-group.Rats of normal control group and LPS-group were killed at 6 hours after intravenous injection of normal saline(8 ml/kg)or LPS(8 mg/kg).The extent of lung injury was assessed by arterial blood gas analysis and histological examination.At the same time,?-ENaC protein and???- ENaC mRNA expression in the lung tissue were analyzed by immunohistochemistry and RT-PCR.Results PaO_2 in LPS-group was noticeably lower than in normal control group(P
