Relationship between combined multigene detection and response to chemotherapy and prognosis in epithelial ovarian carcinomas
- VernacularTitle:多基因蛋白联合检测判断卵巢上皮性癌患者预后的初步探讨
- Author:
Li LI
;
Xiu-Ying MO
;
Wei ZHANG
;
Min-Yi WEI
;
Fa-Long CHEN
;
De-Sheng YAO
;
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Proto-oncogene proteins;
Tumor suppressor proteins;
Tumor markers;
biological;
Immunohistochemistry;
Prognosis
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between combined muhigene detection and response to chemotherapy and prognosis in epithelial ovarian carcinomas(EOCS).Methods A total of 80 ovarian tissue samples taken from the surgical specimens of patients with EOCS of our hospital in the last two decades who had received chemotherapy "after surgery were paraffin-embedded.The samples were divided into 2 groups,good prognosis group(patients who survived more than 2 years,n=46)and poor prognosis group(patients who survived less than 2 years,n=34).The expression levels of ToPo-Ⅱ,Ki-67,MGMT, PCNA,p27,p53,pl6,P-gp,LRP,GST-?,bcl-2,C-myc,Fas,bax,MSH2,MRP and BCRP were investigated by the combination of tissue arrays and immunohistoehemical streptavidin-biotin peroxidase(SP) method in all samples.Data were analysed with SPSS 12.0 for windows.Results There were statistically significant differences in the positive expression levels of P-gp,BCRP,MGMT,MSH2,p27 and p16(62%, 50% and 50% in poor prognosis group vs 33%,28% and 28% respectively,P
