The value of mucin expression profile in endoscopic ultrasound-guided fine needle aspiration pancreatic speci-mens in diagnosing pancreatic cancer
- VernacularTitle:胰腺超声内镜细针穿刺活检组织中粘蛋白表达检测辅助诊断胰腺癌的价值评价
- Author:
Yi WANG
;
Jun GAO
;
Zhao-Shen LI
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Mucins;
Biopsy,fineneedle;
Endosonography
- From:
Chinese Journal of Digestion
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect mucin(MUC1,MUC2,MUC5AC) expressions in endoscopic ultrasound guided fine needle aspiration(EUS-FNA) specimens of the pancreatic neoplasms lesions and evaluate their diagnostic value.Methods The expression profile of MUC1,MUC2,MUC5AC from 54 EUS-FNA samples of pancreatic occupying lesions were examined by immunohistochemistry with mono- clonal antibodies.The results were correlated to the eytohistologic and clinical diagnosis of pancreatic cancer.Results Thirty-eight of the 54 patients had pancreatic cancer,6 patients had benign tumor,10 patients had chronic pancreatitis.The sensitivites of cytology and histology in diagnosing pancreatic cancer were 31.6%and 47.4%,respectively.The prevalence of MUC1,MUC2 and MUC5AC expres- sion in EUS-FNA samples of pancreatic cancer were 81.6%(31/38),10.5%(4/38),84.2%(32/38), respectively,and those in benign pancreatic neoplasms were 25%(4/16),31.3%(5/16),43.8%(7/16),respectively.There was statistically significance in MUCland MUCSAC expression between the two groups(P
