Effect of bcl-xi overexpression in transgene mice with cerebral infarction and study of cytochrome Cexpression and caspase-3 expression
- VernacularTitle:bcl-xl基因过表达在脑梗死中的保护作用及细胞色素C与caspase-3的表达研究
- Author:
Fu-Rong WANG
;
Yong-Sheng JIANG
;
Yan LIU
;
Wen-Wu XIAO
;
Su-Ming ZHANG
;
- Publication Type:Journal Article
- Keywords:
Transgenic mice;
Cerebral infarction;
Bcl-xl;
Cytochrome C;
Caspase-3
- From:
Chinese Journal of Emergency Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).At different time points after ischemia-reperfusion,the expression of cytochrome C and activation of caspase-3 were lower in the transgen mice than that in the wild type rats.Conclusions Under standard condition,overexpression of bcl-xl could significantly reduce the infarct area and improve neurological function in transgene mice than those in the wild type rats.The effect of overexpression of bcl-xl might be realized through inhibiting the apoptosis of neuron,and the mechanism might be that the overexpression of bcl-xl inhibit the release of cytochrome C and the activation of caspase-3.
