Correlation between the expression of HIF-1a in perihematomal brain tissue and formation of brain edema in patients with hypertensive cerebral hemorrhage
- VernacularTitle:脑出血灶周缺氧诱导因子-1a表达与脑水肿的关系
- Author:
Qing-Xin LIU
;
Jin-Bo CHEN
;
Yu-Hong ZHU
;
He-Liang ZHANG
;
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Brain edema;
HIF-1a;
Vascular endothelial growth factor
- From:
Chinese Journal of Emergency Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression of HIF-1a (hypoxia inducible factor 1,HIF-1a) in perihematomal brain issue and formation of brain edema in patients with hypertensive cerebral hemorrhage.Method Perihematomal brain issue was collected in the course of hematoma elimination in 32 patients with hypertemive intraeerebral hemorrhage.Expressions of HIF-1a and vascular endothelial growth factor (VEGF) were observed by immunohistochemistry.The volume of perihematomal brain edema on computed tomographie scan was determined by computed tomographic scan before surgery.The results of staining and the volume of perihematomal brain edema were analyzed in double blind fashion.Results HIF-1a protein immunohistochemical staining positive cells (2.8?0.8/HP) were identified dispersedly from 4 hours after acute hemorrhagic stroke in perihematomal brain issue,and reached the peak at 24～48 hours (12.5?3.9/HP).High expression of HIF-1a progressed at 48～72 hours (12.2?1.8/HP) after acute hemorrhagic stroke.There was a positive correlation between the expression of HIF-1a and VEGF (r=0.76,t=6.37,P
