Protective effects of angiotensin Ⅱ receptors antagonist on the LPS-induced lung acute injury
- VernacularTitle:血管紧张素Ⅱ受体拮抗剂对大鼠内毒素性急性肺损伤的保护作用
- Author:
Hong ZHANG
;
Geng-Yun SUN
;
- Publication Type:Journal Article
- Keywords:
AngiotensinⅡ;
Receptors antagonist;
LPS;
Rats;
Lung injury
- From:
Chinese Journal of Emergency Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of angiotensinⅡ(AngⅡ) receptors antagonist on the LPS-induced acute lung injury (ALl).Method Wistar rats were randomly divided into three groups:control group;in LPS group,mrs were treated with LPS (10 mg/kg) at 3,6,12,and 24 hours;in LPS+ AngⅡreceptors antagonist group,pre-expasure to AngⅡreceptors antagonist [Sar~1,Ile~8] AngⅡfor 30 minutes before treated with LPS (10 mg/kg) for 6 hours.All the rats were killed,and the lung tissue was collected.Results Compared with control group pulmonary wet/dry weight ratio was significantly higher in the other two groups (P
