Serum level of anti-monomer C-reactive protein antibody in systemic lupus erythematosus
- VernacularTitle:红斑狼疮患者血清抗C反应蛋白单体抗体的检测
- Author:
Wei ZHAO
;
Yin SU
;
Ru-Lin JIA
;
Xiao-Yun SUN
;
Zhan-Guo LI
;
- Publication Type:Journal Article
- Keywords:
Autoantibodies;
Lupus erythematosus,systemic;
C-reactive protein;
Enzymelinked immunosorbent assay
- From:
Chinese Journal of General Practitioners
2005;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical significance of anti-momoner C-reactive protein (anti- mCRP) antibody in systemic lupus erythematosus (SLE) and assess the relationship between serum CRP and anti-mCRP antibody.Methods Enzyme-linked immunosorbent assay (ELISA) was applied to determine serum level of anti-mCRP antibody in 113 pateints with SLE,65 patients with other rheumatic diseases,including primary Sjgren syndrome,rheumatoid arthritis,osteoarthritis,ankylosing spondylitis and systemic sclerosis,and 32 healthy controls.Serum level of CRP was evaluated by turbidimetry.Clinical manifestations and laboratory indicators of the patients were all recorded.Results Serum level of anti- mCRP antibody in SLE patients was significantly higher than that in patients with other rheumatic diseases and healthy controls,respectively (t=2.502 and 5.352,respectively,P 0.05).Titer of anti-mCRP antibody closely correlated with systemic lupus erythematosus disease activity index score (r=0.248,P0.05). Conclusions Level of Anti-mCRP antibody increased significantly in patients with SLE,which associated with disease activity of SLE and can be used as a valuable marker in evaluating activity of SLE.
