Effect of peroxisome proliferators-activated receptor ? ligands on cytotrophoblast invasion in first trimester pregnancy
- VernacularTitle:过氧化物酶体增殖物激活受体?及其配体对早孕期绒毛组织及细胞滋养细胞浸润能力的影响
- Author:
Shu-Juan LI
;
Tao SHANG
;
Zi-Qiang CHANG
;
Jun LI
;
Si-Yang LI
;
Qiu-Ling LI
;
Guang-Hai RUI
;
- Publication Type:Journal Article
- Keywords:
Trophoblasts;
Transcription factors;
Receptors,cytoplasmic and nuclear;
Chromans;
Thiazoles;
Prostaglandin D2
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of peroxisome proliferators-activated receptor ? (PPAR?) in trophoblast and relation between PPAR? ligands and trophoblast invasion.Methods We examined the expression of PPAR? by immunohistochemistry,immunocytochemistry and real time quantitative PCR.We next examined,using the cytotrophoblast culture model,the biological role of PPAR? ligands in vitro.Results PPAR? was mainly localized in the nuclei of villous cytotrophoblast and extravillous cytotrophoblast of cell islands and cell columns.In villous tissue and cultured trophoblast from early first trimester,the level of expression of PPAR? mRNA and protein was 36.0?5.1,13.4?3.1 and 1.35?0.08,1.13?0.11;from late first trimester it was 23.3?5.5,6.1?1.3 and 1.17?0.03,0.86 ?0.05,and the expression of PPAR? was obviously decreased (P
