Expressions of monocyte chemoattractant protein-1 in systemic sclerosis
- VernacularTitle:单核细胞趋化蛋白-1在系统性硬化症患者中的表达
- Author:
Ming-Cai ZHAO
;
Chuan-Mei XIE
;
Ming-Hui YANG
;
Jin WEI
;
Jing-Guo ZHOU
;
Guo-Hua YUAN
;
- Publication Type:Journal Article
- Keywords:
Monocyte chemoattractant protein-1;
Scleroderma,systemic;
Enzyme-linked immunosorbent assay
- From:
Chinese Journal of Rheumatology
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of MCP-1 and its correlation with SSc.Methods Twenty-seven patients with SSe and 21 healthy control subjects were examined for MCP-1 expressions by ELISA.mRNA and protein of MCP-1 in fibroblast cells from 5 SSc patients and 3 healthy subjects were also measured by RT-PCR and immunohistochemistry.At the same time,the correlation between the expression levels of MCP-1 and SSc was analyzed.Results The plasma level of MCP-1 was significantly higher in pa- tients with SSc than in healthy control subjects(787?393)pg/ml versus(426?266)pg/ml,P
