Effects of Different Anti-rejection Regimens on Liver Function in Renal Transplant Recipients
- VernacularTitle:不同抗排异组方对肾移植受者肝功能的影响
- Author:
Qing LI
;
Guoqiong LUO
;
Kai TANG
;
Airong YU
;
Xiaochun WU
;
Huawen XIN
;
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Cyclosporine A;
Drug-induced liver damage
- From:
Chinese Journal of Pharmacoepidemiology
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of cyclosporine A coadministrated with azathioprine,mycophenolate, mizorihine,rapamycin and/or prednisone on liver function in renal transplant recipients.Method:The drug history records of 600 renal transplant recipients in 1995 to 2005 were retrospectively investigated.Biochemical indexes before and after the treatment with cyclosporine A coadministrated with other immunosuppressants were analyzed.Result:The liver damage was found in 109 cases(18.2%)among 600 cases.The blood concentrations of cyclosporine A in the group with abnormal liver functions were significantly higher than those in the group with normal liver functions(P
