Meta-analysis of Psychological Side Effects Induced by Fiuoxetine and Amitriptyline in Treating Depression
- VernacularTitle:氟西汀与阿米替林治疗抑郁症副作用Meta分析
- Author:
Yongchun MA
;
Peirong WANG
;
Weidong JIN
;
Jiong CHEN
;
Heqiu WANG
;
Baoping XING
;
Zhenhua TONG
;
- Publication Type:Journal Article
- Keywords:
Depression;
Fluoxetine;
Amitriptyline;
Insomnia;
Anxiety;
Manic disorder;
Meta-analysis
- From:Chinese Journal of Pharmacoepidemiology
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the differences in incidences of insomnia,anxiety(irritability)and manic ep- isode induced by fluoxetine and amitriptyline in treating depression.Method:CBM discs were selected for the data sources. The rates of insomnia,anxiety(irritability)and manic episode from published clinical control trials on depression treated by fluoxetine and amitriptyline were analyzed by applying fixed effect model(FEM)of evidence-based medicine(EBM). Result:Of 1205 cases in 15 studies,the rates of insomnia induced by fluoxetine or amitriptyline were 21.71% and 1.80% ,OR 9.39(95 %CI 5.37-16.44),P0.05.Conclusion:Fluoxetine induces in- somnia and anxiety(irritability)more easily than amitriptyline when treating depression.
