Expression of human leucocyte antigen G on haman placenta and its gene polymorphism in relation to intrahepatic cholestasis of pregnancy
- VernacularTitle:人类白细胞抗原G蛋白在胎盘组织中的表达及其基因多态性与妊娠肝内胆汁淤积症发病的关系
- Author:
Bing PENG
;
Shu-Yun LIU
;
Qiang CHEN
;
Xiao-Dong WANG
;
Li ZHANG
;
Hai ZOU
;
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Cholestasis;
intrahepatic;
Placenta;
HLA antigens;
Histocompatibility antigens class I;
Polymorphism (genetics)
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Conclusions The reduced expression of HLA-G on placenta in ICP patients may alter the maternal-fetal immune response and thus be involved in the pathogenesis of this disorder. Dexamethasone can upregulate the expression of HLA-G on placenta.The 14 bp deletion polymorphism in exon 8 of HLA-G gene might not have a significant influence on the development of ICP.
